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This easy-to-make John Wayne Casserole features a chile-spiced ground beef mixture with bell peppers, tomatoes, and onion with melty cheese, all on top of buttery, flaky biscuits. This beef and biscuit casserole is sure to become a new family favorite!

Baking dish with John Wayne Casserole with a portion served and a golden spoon on the side.


 

This easy-to-make ground beef casserole recipe is a great weeknight dinner for the entire family. This casserole starts with a buttery biscuit crust, followed by layers of ground beef, a medley of diced tomatoes, onions, bell peppers, and a creamy blend of sour cream and mayo mixed with cheese. A generous sprinkling of shredded cheese gives a golden, gooey crust on top that is simply irresistible.

Why is it Called John Wayne Casserole?

This casserole has a complicated history. This particular recipe is not the original, but is inspired by the legendary American actor and his original recipe that was shared in “Cooking with Love from Cara and Her Friends”, compiled by Cara Connery, in 1979.

However its name came about, it’s a great easy and delicious meal that the family will love!

Ingredients Needed

Ingredients needed to make John Wayne Casserole laid out on the counter.
  • Ground Beef: this easy to make beef and biscuit casserole uses one pound of ground beef.
  • Refrigerated Biscuit Dough: this recipe is written using store bought biscuit dough, it is a great time saver, you could bake a layer of homemade biscuits if you prefer. Our favorite store bought biscuits are the Immaculate brand.
  • Onion: diced yellow onion for flavor.
  • Green Bell Pepper: this can be substituted for another color of bell pepper or for a poblano or even a jalapeño if you want a small amount of heat.
  • Mayonnaise & Sour Cream: combined this makes the cream layer of the casserole dish.
  • Diced Tomato: use a can of diced tomatoes or substitute with fresh chopped tomatoes to add to the ground beef mixture.
  • Cheddar Cheese: freshly shredded cheese to mix into the cream layer and to sprinkle on top. You can substitute with another type of melting cheese.
  • Seasonings: chili powder, cumin, salt, pepper, garlic powder, and onion powder are used for flavorings.

how to Make a John Wayne Casserole

Skillet with ground beef, onion, bell pepper and spices.
  1. Cook the ground beef and add the bell peppers, onions, and seasonings.
Bowl of sour cream, mayonnaise and cheese mixed together for John Wayne Casserole.
  1. Combine the mayonnaise, sour cream and some of the shredded cheese to create the creamy layer of the casserole.
  2. Bake the biscuits in the baking dish to create the buttery, biscuit crust for the casserole. Then layer the ground beef mixture, the cream layer, then top with shredded cheese. Bake and add any additional toppings, such as diced tomato or fresh cilantro.
Baked biscuits in a white baking dish.
Ground beef mixture on top of baked biscuits in a baking dish to make a casserole.
Cheese layer added on top of ground beef and biscuit in a white baking dish.

Serving Ideas

Spoon scooping up a serving of John Wayne Casserole from a white baking dish.

Storage Information

  • Storage: keep leftover John Wayne casserole in a sealed container in the refrigerator for 3-4 days.
  • Freezer: allow the casserole to cool completely, then wrap in a layer of plastic wrap, then a layer of foil. Store in the freezer for up to 3 months. Remove to the refrigerator to thaw overnight.
  • Reheating: cover with foil and bake in the oven at 350 degrees for approximately 20 minutes or until warmed through.
John Wayne Casserole in a baking dish after serving showing layers of biscuit, meat and cheese with tomatoes.

More Casserole Recipes

John Wayne Casserole

5 from 2 votes
Prep: 15 minutes
Cook: 30 minutes
Total: 45 minutes
Servings: 6
Author: Serene
This easy-to-make John Wayne Casserole features a chile-spiced ground beef mixture with bell peppers, tomatoes, and onion with melty cheese, all on top of buttery, flaky biscuits. 
Baking dish with John Wayne Casserole with a portion served and a golden spoon on the side.

Ingredients  

  • 8 refrigerated biscuits
  • 1 pound ground beef
  • 1 tablespoon chili powder
  • 1 teaspoon salt
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • ¾ teaspoon ground cumin
  • ½ teaspoon Mexican oregano
  • 1 green bell pepper diced
  • cup onion diced
  • 1 15 ounce can diced tomato
  • ½ cup sour cream
  • ½ cup mayonnaise
  • 2 cups cheddar cheese shredded

Optional Toppings

  • diced tomato
  • fresh cilantro
  • sliced jalapeño

Instructions 

  • Preheat oven to 350 degrees F. 
  • Spray a 9×13 baking dish with cooking spray. 
  • Layer the biscuits in an even layer on the bottom of the dish. 
  • Bake for 15 minutes.
  • While the biscuits bake, cook the ground beef by adding to a medium size skillet over medium heat. Break apart the meat while it cooks. 
  • Add in the bell pepper, onion and seasoning. Stir to coat everything with the seasoning mix and continue to cook until the ground beef is fully cooked and no longer pink. 
  • Stir in diced tomatoes. 
  • In a small bowl combine the sour cream, mayonnaise and 1 cup of the cheddar cheese. Stir to combine. 
  • Once the biscuits have baked for 15 minutes, remove the dish from the oven. Add the ground beef mixture over the top, spreading to create an even layer. 
  • Spoon the cream mixture on top, spreading it out with the back of a spoon to evenly coat the meat. 
  • Top with the remaining shredded cheese. 
  • Bake 20 minutes until the casserole is bubbling along the edges and the cheese is fully melted on top. 
  • Serve while warm. 

Notes

  • Storage: keep leftover John Wayne casserole in a sealed container in the refrigerator for 3-4 days.
  • Freezer: allow the casserole to cool completely, then wrap in a layer of plastic wrap, then a layer of foil. Store in the freezer for up to 3 months. Remove to the refrigerator to thaw overnight.
  • Reheating: cover with foil and bake in the oven at 350 degrees for approximately 20 minutes or until warmed through.

Nutrition

Calories: 526kcal | Carbohydrates: 5g | Protein: 23g | Fat: 46g | Saturated Fat: 17g | Polyunsaturated Fat: 9g | Monounsaturated Fat: 14g | Trans Fat: 1g | Cholesterol: 110mg | Sodium: 833mg | Potassium: 349mg | Fiber: 1g | Sugar: 2g | Vitamin A: 981IU | Vitamin C: 17mg | Calcium: 313mg | Iron: 2mg

Nutrition information is automatically calculated, so should only be used as an approximation.

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Photography by the talented @KJandCompany.co


Welcome to my kitchen!

Welcome to the House of Yumm!! My name is Serene. I’m the food photographer, recipe developer, and official taste tester around these parts.

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1 Comment

  1. Another winner of a recipe!! Hubby loves anything involving biscuits and ground beef. This recipe is so easy to put together and it makes a lot so you can feed a family or have leftovers. I had to use a red bell pepper as I discovered my green ones looked a little old, but it was still delicious! Thank you for another great recipe !